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Pulmonary Hypertension Cardiovascular Health How chronic obstructive pulmonary disease can contribute to congestive heart failure. Changes with pulmonary hypertension: Narrowed air spaces, thick mucus, airways in lung are narrow due to inflammation, big alveoli filled with mucus. Changes in lungs cause constriction of blood vessels. Heart works harder so the right heart fails. These changes are known as Eisenmenger's Syndrome. It looks just like asthma but it's not reversible. © Merck Pharmaceutical, Inc., 2000